Description
Sustanon 250 is a mix of 4 kinds of essential testosterone produced for the purpose of making hormone replacement therapy (HRT) easier to carry out. It’s been used in treating various diseases and eventually found its place in the bodybuilding world. Sustanon 250 embodies all pros of testosterone with the added bonus of easier administration.
History
Sustanon 250 was first produced by the pharmaceutical company Organon and made available for purchase in the early 70’s. Organon wanted to make a more easily administered drug by mixing 4 kinds of essential testosterone. Sustanon 250 was, and still is, one of the best drugs for HRT.
Despite the fact that Sustanon 250 was never approved for medicinal use in the US, it’s become very popular on the international market. This steroid is one of the most widespread ones when it comes to medicine and bodybuilding.
Medical application
Organons were able to produce the perfect HRT drug product by mixing several testosterone esters with varying degrees of activity. Such a mix allowed for testosterone injections as rare as once a month and a more stable level of the hormone’s concentration in the bloodstream during treatment:
- Still, HRT wasn’t the only use for Sustanon 250 in medicine;
- The steroid is also very commonly used for treating stunted growth and maintaining reproductive tissues (testicles, prostate, ejaculatory ducts, penis) to great effect, even at low dosages;
- Moreover, Sustanon 250 has also been used in treating emaciation syndromes of varying origins;
- This is possible due to low doses of Sustanon 250 being able to protect the muscle tissue from dystrophy, making it a popular remedy for HIV-induced slim disease.
Description – Sustanon 250
Sustanon 250 contains a mix of testosterone with 4 esters, which include phenylpropionate, phenylpropionate, isocaproate and decanoate. The ratio is as follows:
- 30 mg of testosterone propionate;
- 60 mg of testosterone phenylpropionate;
- 60 mg of testosterone isocaproate;
- 100 mg of testosterone decanoate.
Esters can affect only the rate of the active components’ absorption, so Sustanon 250 is able to induce all positive effects of testosterone’s high anabolic and androgenic activity. This means more muscle growth and strength improvements for the user.
Even more than that, Sustanon 250 will increase the rate of recovery and improve libido, just like testosterone.
Sustanon 250 vs monoester testosterone
Sustanon 250 has one big advantage when compared to “empty” testosterone or testosterone with only one ester, which is the ability of the ester mix to maintain a more stable level of testosterone in the body due to their differing half-lives.
Consequently, side effects like estrogen spikes or suppressed natural testosterone production can be reduced. In addition, Sustanon 250’s side effects are milder than those of monoester testosterone.
Still, Sustanon 250 shares some side effects and drawbacks of testosterone. Interacting with aromatase enzymes causes testosterone conversion into estrogen, which is why Sustanon 250-induced mass will contain significant amounts of fluid and subcutaneous fat. That is to say, users shouldn’t expect pure muscle out of Sustanon 250. It’s also recommended to combine the drug with anti-estrogens like Nolvadex or Proviron.
The biggest difference between regular testosterone and Sustanon 250 is the admission form.
Sustanon 250 was produced to reduce the frequency of testosterone injections during HRT, and in a lab environment patients need only one injection per month to maintain high levels of testosterone until the next injection. This is made possible by the 4 esters which comprise Sustanon 250.
Sustanon 250 esters
Propionate is the fastest-acting one out of the 4 esters, its half-life is just 2-3 days and its activity starts manifesting extremely quickly. Some studies suggest that it starts producing its effects during the first 24 hours after injections.
Such a short half-life is hard to achieve when it comes to monoester testosterone though. Frequent injections are needed when steroids break down and get excreted from the body so fast, but that’s not a problem for the ester mix containing longer-acting esters for maintaining high levels of testosterone in the bloodstream.
This is why the propionate ester is perfect for a quick increase in testosterone levels when the rest of the esters have only just begun their activity. Thus, when testosterone propionate leaves the body, testosterone phenylpropionate is able to maintain the testosterone level.
Such a fast-acting ester has another benefit as well, but of a more psychological nature – the users’ motivation goes through the roof when they see how quick the steroid starts working.
Testosterone phenylpropionate
Also known as phenylpropionic acid ester, phenylpropionate acts as a bridge between propionate and isocaproate. Testosterone phenylpropionate is somewhat longer-lasting than propionate due to its half-life of 4-5 days. This makes phenylpropionate maintain the stable level of testosterone until propionate is excreted from the body.
The ester can also be found in such nandrolone-based steroids as Deca-Durabolin.
Testosterone isocaproate
Testosterone isocaproate is the next step toward the longest-acting ester of Sustanon 250 called testosterone decanoate. Testosterone isocaproate is also known as isocaproic acid, iso hexanoate and methylvaleric acid.
Testosterone isocaproate has a longer half-life than the phenylpropionate ester, which is about 7-9 days. This is why it’s usually injected once a week when used solo.
Sustanon 250 is not the only testosterone mix with this ester, drugs like Omnadren and Aratest also contain the ester.
Testosterone decanoate
The decanoate ester is one of the longest esters used in steroids, its half-life being more than 2 weeks. Such a half-life makes testosterone decanoate activity last for almost a month! This is why people often think of Sustanon 250 as a monthly drug, but this is true only when it comes to HRT due to its peak activity being reached in less than 2 weeks.
This means that in about 2 weeks the testosterone level will begin to drop, which is problematic for bodybuilders that need to maintain the stable level of the hormone in the bloodstream. So, the decanoate ester allows bodybuilders to inject Sustanon 250 once a week.
The decanoate ester is also known as capric acid, decanoic acid and non-carboxylic acid.
Sustanon 100
The name itself suggests that Sustanon 100 is a lower dosage version of Sustanon 250 (100 mg instead of 250 mg). Sustanon 100 is basically the same as the 250 one, with only two exceptions. First, its dosage is lower than that of Sustanon 250. Second, in contains only 3 essential testosterone kinds instead of 5, and their rate is as follows:
- Testosterone propionate – 20 mg;
- Testosterone phenylpropionate – 40 mg;
- Testosterone isocaproate – 40 mg.
The basic active agent of Sustanon 100 is the same as Sustanon 250, so benefits and side effects are the same as well. The only difference when it comes to the asteroid’s activity is the duration, while dosages are about the same, as are the injection rates.
Still, this version of the drug is much less popular among bodybuilders and is rarely used.
Side effects of Sustanon 250
Sustanon 250 produces the same side effects as other steroids based on testosterone. However, the side effects of Sustanon 250 are milder due to the equal activity of various esters.
Effects like fluid retention and gynecomastia are common as testosterone converts into estrogen. Such effects can be combated with anti-estrogens of the aromatase inhibitor group or selective estrogen receptor modulators (SERMs). Nolvadex and Proviron can be used to avoid side effects associated with estrogen.
Sustanon 250 is also a very potent androgen, which is why it’s possible to encounter such androgen-related effects as greasy skin, acneiform rash, excess facial and/or body hair growth, enlarged prostate and hair loss. Proscar can limit the manifestation of these effects since they’re caused by the dihydrotestosterone (DHT) conversion.
Natural Testosterone Suppression and Cholesterol Levels
Sustanon 250 suppresses natural testosterone production just as the majority of other steroids. Proper post-cycle therapy (PCT) is essential for normalizing testosterone production. Keep one thing in mind, though – supplementary drugs need to be used 2 or 3 weeks after the end of the drug cycle due to the long-lasting activity of Sustanon 250. Drugs like N2Guard and/or Clomid can be used for PCT.
Cholesterol is another problem reported by Sustanon 250 users, as bad testosterone levels can rise after the testosterone cycle. This is why it’s important to follow a healthy diet and take omega-3 fats, probiotics and fiber. Linseed oil can also be used as a natural cholesterol regulator.
Some people say that dosages higher than 500-700 mg per week cause excess sweating and a solvent odor of urine. But these effects are not harmful in the slightest, so they shouldn’t be focused on.
Dosages and usage of Sustanon 250
The common dosages range from 250 to 1000 mg every 7-10 days. Some bodybuilders increase the dosage up to 1500 mg per week, but such consumption can lead to side effects outweighing the benefits of Sustanon 250. The drug cycles shouldn’t last for too long, 12 weeks is usually enough.
The steroid is considered “watery”, so it’s mainly used for mass gain and almost never as a pre-competitive drug. Thus, it’s better to combine Sustanon 250 with Anadrol or Dianabol than to exceed the dosages to achieve more significant and quick effects.
Still, some people combine Sustanon 250 with steroids for cutting like trenbolone or Winstrol to attain tougher and better defined muscles.
Half-life and detection time of Sustanon 250
Half-life of Sustanon 250 is about 15-18 days, detection time is 3 months.
Conclusion
Sustanon 250 is extremely popular among bodybuilders despite the fact that it’s basically just testosterone under a different coat of paint. It was first produced for HRT with the intention of just one injection per month. However, the need of bodybuilders to maintain the stably high levels of testosterone in the bloodstream eliminates this intention, as they use Sustanon once per week.
The steroid is based on testosterone. Which makes side effects associated with estrogen quite significant, with the added possibility of excess water retention. This is why it’s more commonly used as an anabolic-androgenic steroid for mass gain off season.
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