Cytadren (aminoglutethimide) 250mg

Description

Cytadren is another aromatase inhibitor, which was developed earlier on. It was the foremost medication which was accepted for this purpose by most people. Just as testolactone, it was accessible in the market a long time before its functions were fully investigated. As a matter of fact, the history of this medicine is very interesting.

About Cytadren 250mg

It is a derivative of the hypnotic glutethimide and its sale as an anticonvulsant medication began in the United States during 1960. After about 6 years, there were reports of adrenal insufficiency by patients taking this medicine and as a result, it was banned in the market:

• Afterward, this drug was investigated and finally, it was brought back into consumption;
• With the passage of time, Aminoglutethimide came to be one recommended and researched aromatase inhibitor in the market;
• It is also a useful treatment for Cushing’s syndrome when your body produces excessive cortisol; it has a significant effect on cortisol secretion.

The decision pertaining to the dosage of this drug has also been an issue. When it was initially given to patients, it turned out to be effective only momentarily at lowering inhibiting adrenal steroid secretion which lasted for merely 3 to 7 days. It was evident that the body would experience the lowered output of cortisol, and generate more of ACTH in response when dubbed the adrenal escape trend.

This reinstates the normal discharge of adrenal steroids and reverses the outcome of this drug. A small dosage of this medication is used clinically to avert this effect. This was also an accepted practice for the treatment of breast cancer for a while.

Cytadren 250mg Observations

Later on, after thorough investigations, it was found out that the primary system in which this medication is useful for the patients of breast cancer is not the same as which it impedes with adrenal hormones:

• It was also observed that the quantity was essential in initiating each particular reaction;
• It is found out that aromatase inhibition is obtained at a considerably minor dosage than is required to stop the production of steroids by the adrenal gland.

At the same time, as a 1000 mg daily is required to inhibit the demolish enzyme, (it is the enzyme which converts cholesterol to pregnenolone, and is also the target when lesser adrenal production is required), highest inhibition of aromatase and estrogen levels is obtained by 250 to 500 mg.

With regard to the response rate in patients as well, there does not seem to be an advantage by adding cortisol. As a result, there is a need to increase cortisol while using this medicine for inhibiting aromatase and for athletes as well, to apply for a rotating dosage program. Besides, another use for athletes is that of an anti-catabolic, however, this subject requires a separate discussion.

Cytadren 250mg Efficiency

As far as effectiveness is concerned, this drug is extremely effective as it makes aromatase activity decrease as low as 92% only after a dose of 250 mg. The study of the patient’s response proves that this medicine is as good as tamoxifen treatment in healing estrogen-dependent cancer cells, in some specific conditions though.

Because of many functions of this drug including the potential inhibition of cortisol and estrogens as well as aldosterone and androgens, it does not prove to be very comfortable for patients.

This does not imply that the complaints are very common since this drug is well known to be safe. Similarly, athletes can take it as a very useful treatment for estrogenic side effects only if it is accessible at least at the same price as Nolvadex.